AIDS 2012: HIV+ Men Prone to Bone Fractures at Earlier Age

HIV positive men in the long-running MACS cohort appeared to sustain osteoporosis-related bone fractures at an earlier age than HIV negative men, researchers reported at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC. A related study found several factors that predict greater risk of fractures, including use of protease inhibitors and proton pump inhibitors.

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Young Men on Antiretroviral Therapy at Risk for Bone Loss

HIV positive adolescent and young adult men taking antiretroviral therapy (ART) -- especially protease inhibitors -- have lower average bone mineral density than HIV negative men of the same age, researchers reported in the May 9, 2012, advance online edition of Clinical Infectious Diseases.

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HIV/HCV Coinfected People Have Higher Risk of Hip Fractures

HIV positive people who also have hepatitis C virus (HCV) are more prone to hip fractures than people with HIV alone, HCV alone, or neither virus, according to research published in the May 22, 2012, advance online edition of Hepatology.

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Bisphosphonate Drugs Linked to Atypical Femur Fractures, but Absolute Risk is Small

Use of bisphosphonates, a class of drugs used to manage bone loss and prevent fractures, actually appears to increase the likelihood of an unusual type of femur (thigh bone) fracture, according to a retrospective analysis described in the advance online edition of Archives of Internal Medicine. Researchers emphasized, however, that the absolute risk of atypical femur breaks remains very low.

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