Function Imaging Changes May Reflect Brain Impairment during Early HIV Infection

Functional magnetic resonance imaging during the early stages of HIV disease reveals changes in connectivity in the brain that may be due to high-level viral replication soon after infection, according to a study in the September 20, 2011, issue of Brain Connectivity. Researchers suggested this method may be useful as a non-invasive marker for future neurocognitive impairment.alt

Below is an edited excerpt from a media advisory issued by journal publisher Mary Ann Liebert, Inc., describing the study and its findings.

Changes in Brain Function in Early HIV Infection: A Reliable Indicator of Disease Prognosis?

New Rochelle, NY -- October 6, 2011 -- Measurable changes in brain function and communication between brain regions may be a consequence of virus-induced injury during the early stages of human immunodeficiency virus (HIV) infection. These abnormalities and their implications in disease prognosis are detailed in an article in the groundbreaking new neuroscience journal Brain Connectivity, a bimonthly peer-reviewed journal published by Mary Ann Liebert, Inc.

Diminished cognitive function will develop in about half of individuals infected with HIV, which may include deficits in memory, attention, psychomotor capabilities, or verbal fluency. Evidence of cognitive decline in HIV infection has implications for prognosis, reduced survival time, and increased risk of death.

Xue Wang and colleagues from Northwestern University (Chicago and Evanston, IL) and North Shore University Health System (Evanston), used functional magnetic resonance imaging (fMRI) to obtain blood-oxygen-level-dependent measurements in multiple brain regions that yield information on resting-state brain connectivity. They compared the measurements collected in HIV-infected (less than 1 year) and healthy subjects. The authors report "prominent changes" between the two groups in the functional connectivity of visual networks, which have a role in visuo-motor coordination. Based on these findings, they conclude that functional connectivity measurements may be a useful, noninvasive tool for identifying neurological involvement and central nervous system injury early in the course of HIV infection. The findings from the NIH-funded Chicago Early HIV Infection Study are presented in the article, "Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection."

"These findings indicate that changes in brain function are occurring very early in HIV infection, and subclinical alterations in functional connectivity may reflect vulnerability to cognitive decline," says Ann Ragin, PhD, Principal Investigator and Research Professor, Northwestern University Medical School, Chicago, IL.

Investigator affiliations: Department of Radiology, Northwestern University, Chicago, IL; Department of Biomedical Engineering, Northwestern University, Evanston, IL; Center for Advanced Imaging, NorthShore University Health System, Evanston, IL.



X Wang, P Foryt, R Ochs, et al. Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection. Brain Connectivity1(3): 207-217 (abstract). September 20, 2011.

Other Source

Mary Ann Liebert, Inc./Genetic Engineering News. Changes in Brain Function in Early HIV Infection: A Reliable Indicator of Disease Prognosis? Media advisory. October 6, 2011.